RESEARCH ON ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE STRAINS ISOLATED IN SEPSIS PATIENTS AT 103 MILITARY HOSPITAL

Tóm tắt

Objectives: To describe the antibiotic resistance in sepsis patients caused by Klebsiella pneumoniae.
Subjects and methods: A cross - sectional descriptive study of 48 strains of K. pneumoniae isolated in septicemia patients at 103 Military Hospital from January 2017 to June 2021.
Results: 10.4% were hospital - acquired infections. The rate of ESBL (+) accounted for 25.0%. The MDR and XDR strains were 12.5% and 10.4%, respectively. There was no statistically significant difference between ESBL, MDR, and XDR rates between community and hospital - acquired infections (p > 0.05). The K. pneumoniae strains had a high rate of resistance to penicillins (50.0 - 100%), followed by quinolones (25.0 - 28.6%), cephalosporins (21.3 - 25.5%), aminoglycosis (6.0 - 19.0%), carbapenems (7.1 - 14.9%), intermediate resistance to colistin (14.3%). K. pneumoniae strains originating from hospital-acquired infections had higher rates of resistance to amikacin and gentamicin
than strains from community - acquired infections (p < 0.05).
Conclusions: K. pneumoniae strains had a high rate of antibiotic resistance to commonly used antibiotics in clinical practice, and strains with community-acquired infections also had the same antibiotic resistance rates as strains of hospital-acquired infections.