CLINICAL, PARACLINICAL FEATURES OF PATIENTS WITH CYTOMEGALOVIRUS DISEASE AT THE NATIONAL HOSPITAL FOR TROPICAL DISEASES 2020 - 2022

Tóm tắt

Objectives: To describe the clinical and paraclinical characteristics of patients with CMV disease at the National Hospital for Tropical Diseases.
Subjects and methods: Retrospective combined with a prospective cohort study on 58 patients diagnosed with CMV disease treated at the National Hospital of Tropical Diseases in 2 years from January 2020 to June 2022.
Results: In a total of 58 patients with CMV disease, 56.9% of patients were male and the mean age was 45.57 ± 15.7 years. HIV (55.17%), history of prolonged corticoid therapy (20.7%), diabetes (10.34%), alcoholism (3.45%), transplantation (1.72%) were major comorbidities. Common clinical symptoms were:
fever (74.13%), low visual acuity (37.93%), weight loss (31.03%), productive cough (31.03%), headache
(27.59%), lymphadenopathy (24.14%), dry cough (22.41%). 43.1% had monocytosis status, most patients
had normal white blood cell (WBC) count, and slightly increased inflammation markers (ESR, CRP, PCT).
The interquartile range of T-CD4 was48 (11.75 - 215), and 60% of patients had T-CD4 countless than 100
cells/µL. There was no difference between two groups of HIV and non-HIV patients in sex ratio. The HIV
group had higher mean age than non-HIV. Low visual acuity, lymphadenopathy, and weight loss were more frequent in the HIV group, and liver damage was only seen in the non-HIV group.
Conclusion: The study showed that the clinical and paraclinical signs of CMV disease are diverse, nonspecific and need to be considered for screening in patients with suspected symptoms with a history of HIV, prolonged corticoid, diabetes, alcoholism, or transplantation.