STUDY ON THE EFFECT OF NAC IV IN ACUTE EPISODE OF LIVER DYSFUNCTIONS

Tóm tắt

Objectives: Evaluate the effectives and safety of IV NAC in acute episode of liver dysfunctions patient treated in Huunghi Viet Tiep Hospital.
Material and methods: 31 patients treated in Tropical Diseases Department of Huunghi Viet Tiep Hospital who had acute episode of liver dysfunctions from April 15th to July 15th.

Before-after study, compare the results before and after treatment. Beside the original treatment followed the hospital’s guideline, selected patients were received N-acetylcystein IV 100 mg/kg/24h in glucose 5% for 7 days. Patients had health check every day and liver function test was performed before treatment (D0) and on the 3rd and 7th day of treatment or the discharged date (D3 and D7).
Results: After 7 days of treatment, the average value of ALT, AST, and GGT reduced from 626.1 ± 234.8 to 322.5 ± 121.1 (about 50%), from 495.4 ± 178.1 to 127.2 ± 76.5 (about 70%), and from 292.1 ± 88.5 to 227.9 ± 57.4, prospectively. There were 22 patients having high bilirubin value, and after 7 days of treatment, the average reduced 22%. 80.6% patients improved, the average hospital length of stay is 8.68 ± 2.97 days, no patient need for transplant. There was no severe adverse reaction or anaphylactic shock occurred.
Conclusion: NAC IV was safe and effective in preventing the further progression of liver failure.