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Ngày xuất bản: 15/12/2023
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DOI: https://doi.org/10.59873/vjid.v4i44.335
Số xuất bản
Tập 4 Số 44 (2023): Vietnam Journal of Infectious Diseases
Chuyên mục
Nghiên cứu khoa học
Trích dẫn bài báo
Nguyen, T. H., Pham, V. N., Nguyen, H. V., & Le, V. P. (2023). SURVEY ON THE SITUATION OF GROUP B STREPTOCOCCUS INFECTION IN PREGNANT WOMEN OVER 35 WEEKS AT MEDLATEC GENERAL HOSPITAL. Tạp chí Truyền nhiễm Việt Nam, 4(44), 81-86. https://doi.org/10.59873/vjid.v4i44.335

SURVEY ON THE SITUATION OF GROUP B STREPTOCOCCUS INFECTION IN PREGNANT WOMEN OVER 35 WEEKS AT MEDLATEC GENERAL HOSPITAL

Nguyen Thi Hue1,, Pham Van Ngai1, Nguyen Huy Vinh1, Le Van Phung2
1 Medlatec General Hospital
2 Department of Microbiology, Hanoi Medical University

Nội dung chính của bài viết

Tóm tắt

Group B Streptococcus (GBS) is still considered as leading cause of early neonatal infections. Vertical transmission from mother to child may occur when a pregnant woman was infected with GBS in vaginal - rectum at the time of labor or the water breaks of delivery. Therefore, early screening for GBS in pregnant women over 35 weeks is essential to prevent neonatal infection due to GBS.
Objectives: 1) Determine the prevalence of GBS exposure in the vaginal rectum of pregnant women over 35 weeks using cultural and Realtime PCR techniques. 2) Evaluation of the sensitivity of the isolated GBS to antibiotics.
Subjects and methods: Prospective study in 243 pregnant women over 35 weeks who visited and/or had a culture test for Group B Streptococcus at Medlatec General Hospital. Samples of vaginal - rectum fluid were paralelly tested by 2 methods of culture and Realtime PCR. GBS-isolated strains were tested for their susceptibility to antibiotics.


Results: The rate of GBS infection in pregnant women over 35 weeks by culture method is 16.9%, Realtime PCR is 18.9%. The rate of group B Streptococcus sensitive to ampicillin, ceftriaxone, cefotaxime, vancomycin, linezolid are 100%; with levofloxacin at 95.0%, erythromycin at 29.0% and clindamycin at 25.0%.
Conclusions: The rate of Group B Streptococcus infection in pregnant women over 35 weeks as determined by culture method (16.9%), is lower than Realtime PCR (18.9%). Group B Streptococcus is sensitive to most of the first-line antibiotics such as penicillin, ampicillin, ceftriaxone, cefotaxime and is high resistance to erythromycin (68.4%) and clindamycin (72.5%).

Chi tiết bài viết

Từ khóa

GBS, Streptococcus, over 35 weeks, culture, Realtime PCR

Tài liệu tham khảo

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