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CLINICAL, SUBCLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF ADULT INFLUENZA A AND B PATIENTS AT TAM ANH GENERAL HOSPITAL IN 2022
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Tóm tắt
Influenza is an acute respiratory infectious disease caused by the influenza virus. Studies on influenza patients' incidence, complications, and treatment outcomes vary. The COVID-19 pandemic has shown changes in circulating influenza strains.
Objectives: The study aims to describe the clinical, subclinical characteristics and treatment outcomes of
influenza patients to help physicians improve prognosis and treatment outcomes for patients.
Subjects and methods: This cross-sectional descriptive study was conducted on 224 adult influenza patients admitted to Tam Anh General Hospital. The sample was conveniently collected from January 2022 to January 2023.
Result: 61 patients with influenza B (27.2%) and 163 patients with influenza A (72.8%). Clinical characteristics: The average age of the patients was 33.3 years. The most common symptoms were fever, body aches, headache, and productive cough. Biochemical characteristics: Patients had elevated Creatinine levels (0.9%). 45 patients had mildly elevated AST levels (20.1%), and 9 patients had significantly elevated AST levels (2.7%). 30 patients had mildly elevated ALT levels (13.3%), and 10 patients had significantly elevated ALT levels (4.5%).
Treatment outcomes: The average treatment duration for patients in the study was 3.50 ± 1.19 days. Patients with CRP > 2.5 mg/dL had longer treatment durations, higher complication rates, and higher antibiotic use compared to those with CRP ≤ 2.5 mg/dL. 87.5% of patients had good treatment outcomes, with symptoms improving and being discharged from the hospital; 12.5% of patients requested early discharge. Common complications included secondary bronchitis (11.6%), rhinosinusitis (4.4%), and pneumonia (2.2%).
Conclusions: Influenza A predominates among the cases. Patients with CRP > 2.5 mg/dL have a longer average treatment duration, higher complication rates, and increased antibiotic use compared to those with CRP ≤ 2.5 mg/dL.
Chi tiết bài viết
Từ khóa
Influenza, complications of influenza, thrombocytopenia, virus
Tài liệu tham khảo
2. Nguyễn Thị Thu Yến, Lê Thị Quỳnh Mai, Trần Như Dương, Vũ Hải Hà. Tình hình viêm phổi nặng do cúm tại Việt Nam giai đoạn 2006 - 2015.
2015.
3. Sharma Y, Horwood C, Hakendorf P, Thompson C. Clinical characteristics and outcomes influenza A and B virus infection in adult
stralian hospitalised patients. BMC Infect Dis. 20;20(1):913. doi:10.1186/s12879-020-05670-8.
4. 861427138395_CDS_CDS-Guidelines boratory_page20.pdf. Accessed May 22, https://www.copanusa.com/wp-content/uploads/2019/04/861427138395_CDS_CDSGuidelines-Laboratory_page20.pdf.
5. Wæhre T, Tunheim G, Bodin JE, et al. Clinical characteristics and outcomes in hospitalized adult influenza patients: an observational study from Norway 2014-2018. Infect Dis Lond Engl. 2022;54(5):367-377. doi:10.1080/23744235.2021.20 22196.
6. 2020-2021 Flu Season Summary | CDC. Accessed June 8, 2024. https://www.cdc.gov/flu/season/faq-flu-season-2020-2021.htm.
7. Wæhre T, Tunheim G, Bodin JE, et al. Clinical characteristics and outcomes in hospitalized
adult influenza patients: an observational study from Norway 2014-2018. Infect Dis. 2022;54(5):367-377. doi:10.1080/23744235.2021.2022196.
8. Cohen R, Babushkin F, Geller K, Finn T. Characteristics of hospitalized adult patients with laboratory documented Influenza A, B and Respiratory Syncytial Virus - A single center retrospective observational study. PLOS ONE. 2019;14(3):e0214517. doi:10.1371/journal.pone.0214517.
9. Durani U, Dioverti Prono MV, Tosh PK, Patnaik M, Barreto JN, Tande AJ. Influenza infection in neutropenic adults. Infect Dis. 2017;49(2):141-
146. doi:10.1080/23744235.2016.1231418.
10. Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity - PMC.
Accessed May 19, 2024. https://www.ncbi.nlm.nih. gov/pmc/articles/PMC7362372/.
11. Evaluation of Hospitalized Patients with Community-Acquired Influenza-Like Illness During Two Influenza Seasons. Accessed April 11, 2024. https://www.idcmjournal.org/hospitalized-patientswith-influenza-like-illness/.
12. Papic N, Pangercic A, Vargovic M, Barsic B, Vince A, Kuzman I. Liver involvement during influenza infection: perspective on the 2009 influenza pandemic. Influenza Other Respir Viruses. 2012;6(3):e2-e5. doi:10.1111/j.1750- 2659.2011.00287.x
13. Haran JP, Suner S, Gardiner F. Correlation of C-reactive protein to severity of symptoms in acute influenza A infection. J Emerg Trauma Shock. 2012;5(2):149-152. doi:10.4103/0974-2700.96484.
14. Gao R, Wang L, Bai T, Zhang Y, Bo H, Shu Y. C-Reactive Protein Mediating Immunopathological Lesions: A Potential Treatment Option for Severe Influenza A Diseases. eBioMedicine. 2017;22:133- 142. doi:10.1016/j.ebiom.2017.07.010.