PERSONALIZED MEDICINE FOR DIAGNOSIS AND TREATMENT OF NON-SMALL-CELL LUNG CANCER

Ngo Van Lang1,, Hoang Minh Cong2, Nguyen Thi Hue3, Dao Thi Nguyet4, Le Van Thu5, Le Thi Thanh Nhan5, Phan Nguyen Hoang Mai5, Duong Hong Quan5
1 Phenikaa University
2 Yenphong Medical Center
3 Bac Giang General Hospital
4 Duc Giang General Hospital
5 Hanoi University of Public Health

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Tóm tắt

Lung cancer, the most common cause of cancer death worldwide, with most patients dying from distant metastases, has become increasingly complex in achieving effective treatment. In lung cancer, particularly in non-small-cell lung cancer (NSCLC), EGFR, ALK, RET, ROS1, BRAF, KRAS, NRAS, NTRK, PIK3CA,
DDR2, MET, and ERBB2 have been reported as key oncogenic drivers, which have led to the development and application of targeted therapeutic drugs aimed at these dysfunctional genes. Personalized medicine based on these oncogenic drivers offers the greatest potential benefit in the diagnosis and treatment of NSCLC patients. In particular, personalized medicine is importantly recommended for the treatment of advanced NSCLC. Here, we briefly summarize the significant application of personalized medicine based on key oncogenic drivers for the diagnosis and treatment of NSCLC with targeted therapeutic drugs, both globally and Vietnam.

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Tài liệu tham khảo

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