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Ngày xuất bản: 25/11/2024
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DOI: https://doi.org/10.59873/vjid.v4i48.423
Số xuất bản
Tập 4 Số 48 (2024)
Chuyên mục
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Trích dẫn bài báo
Ha, V. Q., Nguyen, D. H., Nguyen, T. X., Le, V. A., & Tran, X. C. (2024). RESEARCH ON PROGNOSTIC FACTORS FOR MORTALITY IN MODERATE TO SEVERE COVID-19 PATIENTS AT THE COVID-19 RESEARCH AND TREATMENT CENTER, HUE CENTRAL HOSPITAL. Tạp chí Truyền nhiễm Việt Nam, 4(48). https://doi.org/10.59873/vjid.v4i48.423

RESEARCH ON PROGNOSTIC FACTORS FOR MORTALITY IN MODERATE TO SEVERE COVID-19 PATIENTS AT THE COVID-19 RESEARCH AND TREATMENT CENTER, HUE CENTRAL HOSPITAL

Ha Van Quyet1,, Nguyen Duc Hoang1, Nguyen Thanh Xuan1, Le Van An2, Tran Xuan Chuong2
1 Hue Central Hospital - Branch 2
2 ue University of Medicine and Pharmacy

Nội dung chính của bài viết

Tóm tắt

Objectives: To investigate the clinical and paraclinical characteristics of moderate to severe COVID-19 patients at the COVID-19 Research and Treatment Center, Hue Central Hospital. To evaluate certain prognostic factors for mortality in moderate to severe COVID-19 patients.
Methods: Patients aged 18 years or older diagnosed with moderate to severe COVID-19 (according to Decision No. 250 of the Ministry of Health, dated January 28, 2022), at the COVID-19 Research and Treatment Center, Hue Central Hospital, from December 2021 to September 2023. This research employed a prospective approach.
Results: A total of 300 patients were enrolled in this study. The average age was 64,57 ± 18,45 years.
The most common comorbidity was hypertension (50.2%). Patients who have been vaccinated (75.3%). The most common clinical signs and symptoms included cough (72%), shortness of breath (56.9%), and fatigue (87.5%). Abnormal paraclinical findings were WBC > 10.109/L (35.7%), LYM < 1.109/L (52.5%), D-dimer > 1000 ng/mL (52.9%), CRP > 10 mg/L (75.5%), Ferritin > 500 ng/mL (52.7%), LDH > 300 U/L (33.2%), positive cytokine storm (23.3%), and TSS 3-6 points (51.9%). The mortality rate was 18%. There was a significant association between underlying conditions, vaccination, LYM, LDH, D-dimer, Ferritin, chest X-rays, cytokine storm, and mortality prognosis in moderate to severe COVID-19 patients (p < 0.05). Non-vaccination was an independent prognostic factor for mortality in moderate to severe COVID-19
patients (OR 2.741; 95%CI: 1.168-6.431; p < 0.005). LDH > 300 U/L was an independent prognostic factor for mortality in moderate to severe COVID-19 patients (OR 6.696; 95%CI: 2.335-19.199; p < 0.001).


Conclusions: Cough, shortness of breath, and fatigue are common symptoms in moderate to severe COVID-19 patients. LYM < 1 x 109/L, D-dimer > 1000 ng/mL, Ferritin > 500 ng/mL, and CRP > 10 mg/L were mainly found in lab tests. The patient mortality rate was 18%. Non-vaccination and LDH > 300 U/L are independent predictors of mortality in moderate to severe COVID-19 patients.

Chi tiết bài viết

Từ khóa

COVID-19, mortality prognosis

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