QUẢN LÝ VÀ ĐIỀU TRỊ TÁI HOẠT ĐỘNG VIÊM GAN B TRÊN BỆNH NHÂN CAN THIỆP LIỆU PHÁP MIỄN DỊCH

Abstract

Hepatitis B virus (HBV) reactivations is a syndrome characterized by the reappearance of HBV particles in patients with previously resolved HBV or an increase in HBV viremia in patients with previously inactive chronic heptitis B (CHB). Viral reactivation can occur spontaneously, but is usually triggered by immunosuppressive therapies (IS). Reactivation of the virus leads to an outbreak of hepatitis B virus, in mild cases patients have elevated liver enzymes leading to delay in chemotherapy, sereve cases can cause acute liver failure leading to death but is preventable if at-risk individuals are identified through screening and started on antiviral prophylaxis (PPX) if indicated. This review emphasizes the importance of screening for hepatitis B in patients receiving immunosuppressive therapy, thereby providing screening measures and risk stratification in each group patient.