KẾT QUẢ ĐIỀU TRỊ VIÊM MÀNG NÃO DO NẤM CRYPTOCOCCUS NEOFORMANS Ở BỆNH NHÂN KHÔNG NHIỄM HIV

Abstract

Cryptococcal meningitis by the fungus Cryptococcus neoformans is a common central nervous system infection found in immunocompromised individuals. The disease often progresses for a long time, difficult to diagnose and has a high mortality rate. In Vietnam, there are a few studies on Cryptococcal meningitis in HIV-uninfected patients.

Objective: This study determines treatment outcomes in patients with Cryptococcal meningitis in non-HIV-infected patients at National Hospital for Tropical Diseases and Center for Tropical Diseases - Bach Mai Hospital.

Subject and methods: Prospective cross-sectional description combined with retrospective. 45 patients were diagnosed with meningitis caused by Cryptococcus neoformans not infected with HIV from 1/2016 - 6/2020.

Results and conclusions: 45 patients eligible for inclusion in the study, mean age of study patients was 48.9 ± 14,6 years, 53.3% (24/45) of patients were male and 33.3% (15/45) of patients classified as elderly (≥ 60 years old), the average treatment time of patients in the study was 25.8 ± 17.8 days, the mortality/severe request for return was 31.1%, and discharge from hospital and lower level referral assistance was 68.9%.