ĐỊNH DANH LOÀI VÀ ĐÁNH GIÁ MỨC ĐỘ NHẠY CẢM VỚI THUỐC KHÁNG NẤM CỦA VI NẤM CANDIDA PHÂN LẬP TỪ ĐƯỜNG TIÊU HÓA BỆNH NHI SƠ SINH TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC HUẾ

Abstract

Introduction: Candida colonization of the gastrointestinal tract is common in the newborn population. This fungus can cause oral thrush, a common disease in neonates. Besides, Candida is one of the most neonatal nosocomial pathogens in pediatric ICU. 

Objective: 1.To identify Candida colonization species isolated from the digestive system of neonates. 2. To evaluate antifungal susceptibility testing of Candida isolates. 

Material and methods: A cross-sectional study was carried out from patients admitted in Neonates ward, Obeotric Department, Hue University of Medicine and Pharmacy Hospital from 1.2020 to 12.2020. Patients’ oral swab and stool were collected to check fungi by a direct examination and cultivate to identify fungal species. Antifungal susceptibility testing was carried by the disc diffusion method. 

Results and coclusions: The prevalence of Candida colonization in the digestive system of neonates was 28.83%. In which, the rate of C .non albicans was higher than C. albicans (76.67% vs 23.33%). There wasn’t any resistance of Candida to amphotericine and nystatin. The resistance prevalence of Candida to fluconazole, itraconazole, voriconazole, caspofingin, and 5-flucystosin were 6.67%, 3.33%, 3.33%, 23.33% and 16.66% respectively. C. albicans was susceptible to azoles and caspofungin, meanwhile C. non albicans was resistance to those drugs. The resistance rate of C. albicans to 5-flucytosin was higher than C. non albicans (p<0.05). Resistance to more than 2 drugs was recognized in 34.78% of C. non albicans.