NGHIÊN CỨU MỘT SỐ ĐẶC ĐIỂM CỦA KHÁNG NGUYÊN LIÊN QUAN LÕI VIRUS VIÊM GAN B TẠI TRUNG TÂM Y KHOA MEDIC THÀNH PHỐ HỒ CHÍ MINH

Abstract

Objectives: To describe some of the characteristics of hepatitis B core - related antigen (HBcrAg) and determine the correlation coefficient of HBcrAg and serum HBV DNA concentration in chronic hepatitis B.

Subjects and methods: This cross - sectional descriptive study and analysis included 106 cases at MEDIC Medical Center Ho Chi Minh city from November 2019 to July 2020. HBcrAg wasdetected by chemiluminescent enzyme immunoassays. Serum HBV DNA was detected by real -time PCR.

Results: The rate of HBcrAg - positive patients in study was 71.7%, the mean HbcrAg concentration was 4.15 ± 1.63 log U/mL, distribution range was 2.0 - 7.0 log U/mL. The meanHBcrAg concentration was significantly difference by age group, ALT elevation, specifictreatment, HBeAg status and serum HBV DNA levels. The serum HBcrAg concentration correlated with the serum HBV DNA levels in a positive and linear manner with correlation coefficient r = 0.75 in the treatment - naïve patients and r = 0.40 in the treatment – experienced patients.

Conclusions: The study showed a significant difference in mean HBcrAg concentration in the ALT - increased group and in the normal ALT group; in the HBeAg - negative group and HBeAg- positive group; in the undetectable serum HBV DNA group and detectable HBV DNA group. The correlation coefficient between serum HBcrAg and HBV DNA in the study sample was well correlated with r = 0.75 in the patients who were treatment - naïve and r = 0.40 in the patients who were treated with nucleos(t)ide analogues (NAs).