TÍNH KHÁNG KHÁNG SINH CỦA STAPHYLOCOCCUS GÂY NHIỄM KHUẨN HUYẾT TRÊN NGƯỜI BỆNH CÓ BIẾN CHỨNG VIÊM NỘI TÂM MẠC (1/2018 – 6/2022)

Abstract

Objective: Describle the clinical and antibiotic-resistant of Staphylococcus among the sepsis patients complicated endocarditis at National Hospital of Tropical Disease and Bach Mai Hospital.

Subjects and methods: Cross-sectional description of 105 inpatients at at National Hospital of Tropical Disease and Bach Mai Hospital from January 2018 to June 2022.

Result: Most patient were male (71.4%) and common in the age group of  29 – 60 years old (56.4%). Most of the patient had no history of valvular heart disease(65.7%). The most common etiology is S.aureus (81%). The rate of methicillin resistance was 61.9% and there was a difference in antibiotic - resistance between the 2 groups with valvular heart diseaseand no history of valvular heart diseasewith 1st and 2nd generation cephalosprins and β-lactams have β-lactamase enzymes. S.aureus also has similar antibiotic resistance and tends to increase to cephalosporin and aminoglycosid groups, no strains resistant to vancomycin, tygecyclin and teicoplanin have been detected.

Conclusion: Staphylococcus associated sepsis in patients with valvular heart diseaseis forceful caused by S.aureus. In which, the antibiotic resistance rate of Staphylococcus and tends to increase the rate of antibiotic resistance with cephalosporin and aminoglycosides.