TỶ LỆ KHÁNG KHÁNG SINH CỦA CÁC CHỦNG STENOTROPHOMONAS MALTOPHILIA PHÂN LẬP TRÊN BỆNH NHÂN ĐIỀU TRỊ TẠI BỆNH VIỆN ĐA KHOA TỈNH BẮC GIANG

Abstract

Objective: To determine the resistance rate of Stenotrophomonas maltophilia (S. maltophilia) strains to antibiotics that isolated in patients treated at Bac Giang Provincial General Hospital.

Subjects and methods: A cross-sectional, retrospective descriptive study of 111 medical records of patients whose infected with S. maltophilia treated at Bac Giang Provincial General Hospital from June 1, 2018 to May 31, 2022.

Results: The rate of S. maltophilia resistant to antibiotics included in the CLSI testing and interpretation guidelines: Group A: 18.9% resistant to minocyclin, 7.2% resistant to levofloxacin, 25.2% resistant to trimethoprim/sulfamethoxazole (SXT), Group B: 72 .1% resistant to ceftazidime, Group C: 74.8% resistant to Chloramphenicol, Group O: 29.7% resistant to ticarcillin/clavulanate. S. maltophilia, instrinsict resistant to many antibiotics of aminoglycoside, cephalosporin, carbapenem, some quinolone antibiotics... 99.1% of S. maltophilia strains had MIC with piperacyllin/ tazobactam ≥ 126/4 µg/ml ; 84.7% had MIC with ciprofloxacin ≥ 2 µg/ml; 22.5% had MIC with colistin ≥ 4 µg/ml; 43.2% had MIC with tigecyclin ≥ 8 µg/ml; 45.9% strains of S. maltophilia had multi drug resistance, of which 27.0% were multi drug resistant, 13.5% were expensive drug resistant, and 5.4% were pan drug resistent.

Conclusion: S. maltophilia were resistant to many antibiotics with many different  degrees of resistant. Rate of S. maltophilia resistant to antibiotics: 18.9% resistant to minocyclin; 27.9% resistant to levofloxacin; 25.2% resistant to SXT. 72.1% resistant to ceftazidime, 4.5% intermediate. Regarding the resistance profile, there were 45.9% multi drug resistant strains of S. maltophilia.