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STUDY OF PREVALENCE OF ORAL CANDIDA INFECTION IN PATIENTS UNDERGOING THERAPY AT THE ONCOLOGY DEPARTMENT OF HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
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Abstract
Introduction: Candida spp. species are the most common fungal pathogens in the world. Oral Candida infection is common in cancer patients undergoing chemotherapy. This study aimed to investigate the prevalence of oral Candida infection in patients being treated in the oncology department and investigate the morphological characteristics of the fungus, to assess the diagnostic techniques for oral Candida infection.
Materials and methods: A descriptive cross-sectional study, using laboratory wet mount examination to investigate the morphology of fungi, cultured in Sabouraud's medium with chloramphenicol to isolate the fungus, determination of Candida albicans and non-albicans Candida by Chromogenic agar medium.
Results: The study carried out on 120 patients being treated at the Oncolgy Department. In which, there were 45.8% with oral Candida infetions including: Candida albicans 70.9% and non albicans Candida 29.1%. The prevalence of Candida infection in chemotherapeutic patients were higher than non-chemotherapeutic ones. Direct technique for oral Candida infection diagnostic had 72.72% of sensitivity and 78.46% of specificity.
Conclusions: The prevalence of oral Candida infection was 45.8% including: Candida albicans 70.9% and non albicans Candida 29.1%. The incidence of oral Candida infection was higher in patients with risk factors and clinical symptoms of oral thrush. Yeast cells and pseudohyphaes were the character of Candida spp.. Direct technique for oral Candida diagnostic had 72.72% of sensitivity and 78.46% of specificity.
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Keywords
Oral Candida infection, chemotherapy
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