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Date Published: 20/06/2023
Abstract Views: 2397
Views PDF: 1480
DOI: https://doi.org/10.59873/vjid.v2i42.289
Issue
Vol. 2 No. 42 (2023): WARM WELCOME TO THE SECOND EXPANSIONAL SCIENTIFIC CONFERENCE ON INFECTIOUS DISEASES AND TROPICAL DISEASES IN THE CENTRAL REGION AND THE WEST HIGHLAND OF VIETNAM IN YEAR 2023
Section
Scientific research
How to Cite
Phan, T. M. T., & Tran, X. C. (2023). PROGNOSTIC VALUE OF APRI IN DENGUE FEVER. Vietnam Journal of Infectious Diseases, 2(42), 102-105. https://doi.org/10.59873/vjid.v2i42.289

PROGNOSTIC VALUE OF APRI IN DENGUE FEVER

Thi My Tram Phan, Xuan Chuong Tran

Main Article Content

Abstract

In recent decades, Dengue fever has been recognized as one of the infectious diseases with the highest morbidity and mortality rates in the world. The disease is currently endemic in more than 129 countries, mainly in tropical and subtropical regions, with Asia accounting for about 70% of the global disease burden. In Vietnam, the disease has also become a serious medical problem. In 2022, the whole country has more than 300,000 cases with 115 deaths. Understanding the prognostic factors helps to detect severe cases early and reduce the mortality rate caused by the disease.


In Dengue fever, liver damage and thrombocytopenia are very common clinical manifestations. The combination of two indicators of increased transaminases and thrombocytopenia through APRI has been significant in predicting disease severity in many studies. A 2019 study showed that a high APRI differentiated patients with Dengue and severe Dengue with a sensitivity of 60.53% and a specificity of 79.89%. In 2021, a study was conducted on 4069 Dengue patients showed that an APRI value ≥ 19.18 had a predictive significance of 100%. Another study in 2023 showed with a cut-off value of 2.5, the sensitivity and specificity of the APRI value for predicting disease severity were 80.0% and 76.8%, respectively. In addition, another study showed that the APRI index helped differentiate primary and secondary Dengue infection with sensitivity and specificity of 75% and 76% with an APRI cut-off of 1.06.


Thus, through the studies, APRI is considered as a useful tool to help distinguish primary and secondary Dengue infection as well as to predict the severity of the disease, which is meaningful in early detection and timely treatment and reduce mortality from Dengue fever.

Article Details

Keywords

Dengue fever, prognosis, APRI

References

1. Đỗ Tuấn Anh, Lê Văn Nam (2014), "Nghiên cứu một số yếu tố tiên lượng nặng ở bệnh nhân sốt xuất huyết Dengue điều trị tại Khoa Truyền nhiễm, Bệnh viện 103 năm 2011-2012", Tạp chí Y học thực hành. 1(902).
2. Bộ Y tế (2019), "Hướng dẫn chẩn đoán, điều trị sốt xuất huyết Dengue", Tài liệu hướng dẫn của Bộ Y tế.
3. Nguyễn Mậu Thạch (2021), Nghiên cứu đặc điểm lâm sàng, cận lâm sàng của bệnh sốt xuất huyết Dengue ở trẻ em tại Bệnh viện Sản Nhi Quảng Ngãi, Luận văn chuyên khoa cấp II.
4. Basu, Atanu, et al. (2008), "Dengue 2 virus inhibits in vitro megakaryocytic colony formation and induces apoptosis in thrombopoietin-inducible megakaryocytic differentiation from cord blood CD34+ cells", FEMS Immunology & Medical Microbiology. 53(1), pp. 46-51.
5. Fiestas Solórzano, Victor Edgar, et al. (2021), "Different profiles of cytokines, chemokines and coagulation mediators associated with severity in Brazilian patients infected with Dengue virus", Viruses. 13(9), p. 1789.
6. Guedes, Karla Sena, et al. (2019), "Aspartate aminotransferase-to-platelet ratio index (APRI): A potential marker for diagnosis in patients at risk of severe malaria caused by Plasmodium vivax", PLoS One. 14(11), p. e0224877.
7. Jayanthi, Hari Kishan and Tulasi, Sai Krishna (2016), "Correlation study between platelet count, leukocyte count, nonhemorrhagic complications, and duration of hospital stay in Dengue fever with thrombocytopenia", Journal of family medicine and primary care. 5(1), p. 120.
8. Leowattana, et al. (2021), "Dengue hemorrhagic fever and the liver", World Journal of Hepatology.
13(12), p. 1968.
9. Martins, Suellen R, et al. (2018), "Aspartate aminotransferase to platelet ratio index (APRI) for differentiation of primary and secondary infection by Dengue virus", Jornal Brasileiro de Patologia e Medicina Laboratorial. 54, pp. 273-278.
10. Murray, Natasha Evelyn Anne, et al. (2013), "Epidemiology of Dengue: past, present and future prospects", Clinical epidemiology. 5, p. 299.
11. Percy Priyanka T., et al., (2023), "The aspartate aminotransferase platelet count ratio index as an ideal predictor of Dengue severity", International Journal of Advances in Medicine. 10(1), pp. 49-53.
12. Sarkar, Joy, DeLeon, et al. (2017), "MELD score and AST-to-platelet ratio index (APRI) predict long-term survival in patients with a small hepatocellular carcinoma following non-transplant therapies: a pilot study", Hepatoma research. 3, p. 79.
13. Şaşmaz, Muhammed İkbal, et al. (2020), "Aspartate-aminotransferase to platelet ratio index score for predicting HELLP syndrome", The American Journal of Emergency Medicine. 38(3), pp. 459-462.
14. World Health Organization (2020), Dengue and severe Dengue, Geneva.
15. Yeh, Chun-Yin, et al. (2019), "Trajectories of hepatic and coagulation dysfunctions related to a rapidly fatal outcome among hospitalized patients with Dengue fever in Tainan, 2015", PLoS neglected tropical diseases. 13(12), p. e0007817.