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Date Published: 20/06/2023
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DOI: https://doi.org/10.59873/vjid.v2i42.290
Issue
Vol. 2 No. 42 (2023): WARM WELCOME TO THE SECOND EXPANSIONAL SCIENTIFIC CONFERENCE ON INFECTIOUS DISEASES AND TROPICAL DISEASES IN THE CENTRAL REGION AND THE WEST HIGHLAND OF VIETNAM IN YEAR 2023
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Scientific research
How to Cite
Doan, H. T., & Tran, X. C. (2023). UPDATES ON DIAGNOSIS AND TREATMENT OF ACUTE LIVER FAILURE IN PATIENTS WITH CHRONIC HEPATITIS B (HBV-ACLF). Vietnam Journal of Infectious Diseases, 2(42), 106-112. https://doi.org/10.59873/vjid.v2i42.290

UPDATES ON DIAGNOSIS AND TREATMENT OF ACUTE LIVER FAILURE IN PATIENTS WITH CHRONIC HEPATITIS B (HBV-ACLF)

Hieu Trung Doan, Xuan Chuong Tran

Main Article Content

Abstract

Acute-on-chronic liver failure (ACLF) is defined by The World Gastroenterology Organization (WGO) is a syndrome in patients with chronic liver disease with or without previously diagnosed cirrhosis characterized by acute hepatic decompensation resulting in liver failure (jaundice and prolonged INR) and one or more extrahepatic organ failure associated with increased mortality within a period of 28 days to 3 months from the onset. Systemic inflammation is a key feature of ACLF and an excessive inflammatory response is associated with poor outcomes. In patients with hepatitis B virus-associated ACLF (HBV-ACLF), severe systemic inflammation is an important event leading to liver injury. However, the initiation events of HBV-ACLF are not well known; Furthermore, the effects of these events on host immunity as well as immune imbalances in the progression of HBV-ACLF are not well understood. Treatment is mainly focused on supporting various organ failure while waiting for the liver to recover or waiting for a liver transplant. Liver transplantation remains the most effective treatment for HBV-ACLF. Conservative treatments such as nucleos(t)ide analog antivirals (NUCs), especially glucocorticoid therapy and and artificial liver support can improve the survival rate in some patients with HBV-ACLF. This overview provides an update on some new points in the diagnosis and treatment of HBV-ACLF from current clinical studies

Article Details

Keywords

ACLF, HBV-hepatitis B virus, inflammation, cytokines storm

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