TÌNH TRẠNG KHÁNG KHÁNG SINH CỦA MỘT SỐ CĂN NGUYÊN VI KHUẨN GÂY NHIỄM KHUẨN HUYẾT TẠI TRUNG TÂM BỆNH NHIỆT ĐỚI BỆNH VIỆN HỮU NGHỊ ĐA KHOA NGHỆ AN

Abstract

Objectives: To determine the prevalence and antibiotic resistance profile of some common bacteria causing sepsis.

Subjects and methods: This cross-sectional study was carried out on 229 inpatients treated at the Tropical Diseases Center of Nghe An General Hospital with a confirmed diagnosis of sepsis between January 2020 and April 2022..

Results: The average age of the study subjects was 61.2 ± 14.7 years old with 58.9% male and 41.1% female patients. The rate of isolation of gram-negative bacteria was 76.4% and for gram-positive bacteria was 23.6%; the most common bacteria causing sepsis are E. coli (42.8%), S. aureus (15.3%), B. pseudomonas (15.3%), K. pneumoniae (13.1%). E. coli has high resistance to cephalosporin (50.5% - 64.5%), fluoroquinolone (36.8 - 38.4%), low resistance to amikacin (2.1%), not yet resistant to carbapenem. B. pseudomallei was 100% sensitive to doxycycline, ceftazidime, meropenem and 67.7% to trimethoprim-sulfamethoxazole. K. pneumoniae is more than 70% sensitive to 3rd generation cephalosporins, over 80% to quinolones, aminoglycosides and over 90% to carbapenems. S. aureus resistant to erythromycin (73.9%), clindamycin (69.7%), fluoroquinolone (14.7 - 17.7%), resistance to vancomycin, linezolide has not been recorded.

Conclusions: The bacteria are usually highly resistant or partially resistant to the antibiotics cephalosporin, and quinolone but are still highly sensitive to carbapenem (gram-negative bacteria) and Vancomycin, Linezoliede (gram-positive bacteria).