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Date Published: 15/03/2024
Abstract Views: 468
Views PDF: 282
DOI: https://doi.org/10.59873/vjid.v1i45.343
Issue
Vol. 1 No. 45 (2024)
Section
Scientific research
How to Cite
Tran, X. C., & Quach, K. U. (2024). EPIDEMIOLOGICAL CHARACTERISTICS IN PATIENTS WITH COINFECTION HIV/HBV IN SOME DISTRICS IN HO CHI MINH CITY. Vietnam Journal of Infectious Diseases, 1(45), 12-19. https://doi.org/10.59873/vjid.v1i45.343

EPIDEMIOLOGICAL CHARACTERISTICS IN PATIENTS WITH COINFECTION HIV/HBV IN SOME DISTRICS IN HO CHI MINH CITY

Xuan Chuong Tran, Kim Ung Quach

Main Article Content

Abstract

Background: HBV co-infection with HIV is quite common. People with HBV/HIV co-infection may have more liver damage, more severe disease progression. Research into the therapeutic effects of HIV/HBV coinfection is urgently needed.
Research objectives: To evaluate the results of first-line ART treatment of HIV/HBV co-infected patients in some districts in Ho Chi Minh City.
Subjects and methods: 69 HIV/AIDS patients aged 18 years or older with HBV co-infection, were being treated at some outpatient clinics (OPCs) in 4 districts of Ho Chi Minh City.
Results: Clinical and subclinical characteristics of HIV/HBV coinfected patients: Age of disease 31.2 ± 8.9 years old. Male patients 95.7%, female patients 4.3%. 81.2% of HIV/HBV coinfected patients had no clinical symptoms. 5.8% of patients had symptoms of pharyn’s fungus, weight loss 4.3%, the average CD4 count at hospital was 347.58 ± 225.47 cells/mm3 The mean HBV DNA load was 4.46 ± 1.84 log10 (copies/ml). The mean AST was 37.36 ± 21.11 U/L; Mean ALT (39.19 ± 20.82 U/L). After 12 months of treatment, CD4 < 200 (cells/mm3) from 23.2% before treatment decreased to 10.1% after 6 months and 7.9% after 12 months. After 12 months, 89.5% of patients had HIV RNA loads below the inhibitory threshold. 84.2% and 76.3% had AST and ALT returned to normal values, the proportion of HBV DNA undetectable was 86.8%.
Conclusions: After 12 months, 89.5% of patients had HIV RNA loads below the inhibitory threshold. 84.2% and 76.3% had enzyme AST and ALT returned to normal values, the proportion of HBV DNA undetectable was 86.8%.

Article Details

Keywords

HIV, HBV, HIV/HBV co-infection, ARV treatment

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