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GLYCATED HEMOGLOBIN (HBA1C) AND RISK OF VENTILATOR ASSOCIATED RESPIRATORY INFECTION (VARI)
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Abstract
Background: VARIs are common hospital acquired infections (HAIs) in intensive care units (ICUs) with worrisome clinical outcomes. Studies about association between diabetes and VARI is scarce and controversial. However, diabetes was mostly diagnosed by patients’ medical histories which could cause isclassification errors.
Subjectives: The aim of this study was to compare the clinical characteristics of individuals with different levels of HbA1c and to investigate the association between HbA1c and the risk of developing VARI in ICU population.
Methods: 562 adult patients intubated for ≤ 24h at the time of enrolment were divided by their HbA1c on admission into 3 categories (< 5.7%, 5.7 - 6.4%, ≥ 6.5%). VARI episodes were recorded up to 90 days after randomization.
Results: ICU stay until the appearance of the first VARI episode between the 3 groups of patients was not statistically significant (P = 0.0603). The risk of developing VARIs was not different in patients with HbA1c between 5.7% - 6.4% (ảnh hưởng R= 0.88 [0.58 - 1.34], p = 0.552) and ≥ 6.5% (aHR 0.88 [0.5 - 1.56], p = 0.663) as compared to those with HbA1c < 5.7%. Conclusion: We found no association between HbA1c and VARI.
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Keywords
Nhiễm khuẩn hô hấp liên quan đến thở máy, HbA1c, đái tháo đường, khoa hồi sức tích cực
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