CLINICAl EPIDEMIOLOGICAL CHARACTERISTICS AND SOME FACTORS RELATED TO SEVERE BRONCHIOLITIS IN CHILDREN INFECTED WITH RESPIRATORY SYNCYTIAL VIRUS AT NATIONAL CHILDREN’S HOSPITAL

Van Tinh Nguyen, Thi Thuy Hong Nguyen, Thi Hong Le, Minh Tuan Pham

Main Article Content

Abstract

Objectives: To describe clinical epidemiological characteristics and some factors related to severe bronchiolitis in children infected to respiratory syncytial virus (RSV) at the National Children's Hospital.
Subjects and methods: A cross-sectional descriptive study, including 344 bronchiolitis patients infected with RSV, including 121 children in the mild - moderate group, 223 children in the severe group treated at the Respiratory Center of the National Children's Hospital.
Results: Among 344 children with bronchiolitis infected with RSV, 86.3% were children under 12 months, the group of children under 3 months accounted for the highest rate was 42.7%, the ratio of boys : girls was 2.01/1, the number of sick children increases in the summer months. Clinical manifestations such
as cough and wheezing are the most common symptoms of bronchiolitis. Signs such as rapid breathing, chest indrawing or changes in consciousness (excitability or lethargy) were common in the severe group, with a high rate. Age less than 6 months, premature birth, birth weight less than 1500 grams, comorbidities are factors related to the severity of bronchiolitis.
Conclusions: Bronchiolitis with RSV infection in children has had epidemiological changes after COVID-19 when the epidemic broke out in the summer months, the disease was more common in boys than girls, mainly in children under 12 months old. The most common symptoms are cough, wheezing and shortness of breath. In particular, the severe form shows more severe shortness of breath, signs of exertion and affects the child's mental state such as irritability or lethargy. The factors that have been shown to be associated with severe condition are less than 6 months, premature birth, birth weight less than 1500 grams, children with underlying diseases. 

Article Details

References

1. Trần Quỵ. Viêm tiểu phế cấp ở trẻ em. In: Sách giáo khoa nhi khoa (Textbook of Pediatrics). NXB Y học; 2016:711-716.
2. Coates B, Camarda L, Goddman D. Wheezing, bronchiolitis, and bronchitis. In: Nelson Textbook of Pediatrics. 20th ed. Philadenphia; 2016:2045-2049.
3. Stempel HE, Martin ET, Kuypers J, et al. Multiple viral respiratory pathogens in children with bronchiolitis. Acta Paediatr Oslo Nor 1992. 2009;98(1):123-126. doi:10.1111/j.1651-2227.2008.01023.x
4. Friedman JN, Rieder MJ, Walton JM, Canadian Paediatric Society, Acute Care Committee, Drug Therapy and Hazardous Substances Committee. Bronchiolitis: Recommendations for diagnosis, monitoring and management of children one to 24 months of age. Paediatr Child Health. 2014;19(9):485-498. doi:10.1093/pch/19.9.485.
5. 1 Recommendations | Bronchiolitis in children: diagnosis and management | Guidance | NICE. Accessed April 24, 2022. https://www.nice.org.uk/guidance/ng9/chapter/1 Recommendations#assessment-and-diagnosis.
6. O’Brien S, Borland ML, Oakley E, et al. National guidelines for bronchiolitis. J Paediatr Child Health. 2019;55(6):728. doi:10.1111/jpc.14463.
7. Tran DN, Pham TMH, Ha MT, et al. Molecular epidemiology and disease severity of human respiratory syncytial virus in Vietnam. PloS One. 2013;8(1):e45436. doi:10.1371/journal.pone.0045436.
8. Gökçe Ş, Kurugöl Z, Koturoğlu G, et al. Etiology, Seasonality, and Clinical Features of Viral Respiratory Tract Infections in Children Hospitalized With Acute Bronchiolitis: A Single-Center Study. Glob Pediatr Health. 2017;4:2333794X17714378. doi:10.1177/2333794X17714378.
9. Trần Thanh Tú, Nguyễn Thị Thanh Phúc. Một số đặc điểm dịch tễ học viêm đường hô hấp dưới cấp tính do vi rút ở trẻ em 2 tháng đến 2 tuổi khám tại Bệnh viện Nhi Trung ương. Accessed April 24, 2022. http://www.tapchiyhocduphong.vn/tap-chi-y-hoc-du-phong/2014/04/mo-t-so-dac-diem-dich-te-hoc-viem-duong-ho-hapduoi-cap-tinh-do-vi-ru-t-o-tre-em-o81E2016D.html.
10. Nguyen SN, Nguyen TNT, Vu LT, et al. Clinical Epidemiological Characteristics and Risk Factors for Severe Bronchiolitis Caused by Respiratory Syncytial Virus in Vietnamese Children. Int J Pediatr. 2021;2021:9704666. doi:10.1155/2021/9704666.
11. Lê Thị Thu Trang, Lê Hồng Hanh, Phùng Đăng Việt. Nghiên cứu vai trò của virus trong bệnh viêm tiểu phế quản nặng tại viện nhi trung ương 2011. Tạp Chí Lao Và Bệnh Phổi. Published online 2011:72-75.
12. Hervás D, Reina J, Yañez A, et al. Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2012;31(8):1975-1981. doi:10.1007/s10096-011-1529-y
13. Mecklin M, Heikkilä P, Korppi M. Low age, low birthweight and congenital heart disease are risk factors for intensive care in infants with bronchiolitis. Acta Paediatr Oslo Nor 1992. 2017;106(12):2004-2010. doi:10.1111/apa.14021.
14. Holman RC, Shay DK, Curns AT, et al. Risk factors for bronchiolitis-associated deaths among infants in the United States. Pediatr Infect Dis J. 2003;22(6):483-490. doi:10.1097/01.inf.0000069765.43405.3b.