NGHIÊN CỨU TỶ LỆ VÀ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG NHIỄM SIÊU VI VIÊM GAN B TIỀM ẨN TẠI TRUNG TÂM Y KHOA MEDIC THÀNH PHỐ HỒ CHÍ MINH

Abstract

Introduction: The Taormina Consensus Conference (Italy, 2008 and 2018) defined occult hepatitis B virus infection (OBI) as the presence of hepatitis B virus DNA in the hepatocytes or serum of individuals who had tested negative for serum HBV surface antigen with currently available assays. OBI can lead
to viral reactivation; it may have a detrimental effect on the progression of chronic liver disease towards advanced clinical stages; it has a significant role in the development of hepatocellular carcinoma (HCC).
Objectives: (a) Determine the rate of OBI at the study site; (b) Describe the clinical and paraclinical characteristics of the OBI patient group.
Subjects and methods: Cross-sectional description with analysis on a study sample of 753 patients with negative HBsAg and positive anti-HBc total tested for HBV DNA by PCR.
Results: The rate of OBI at the study site was 6.4% (48/753 patients). The average age of OBI was 53 ± 12 years, mainly in the age group ≥ 30, male accounted for 47.9%, female accounted for 52.1%. The majority had no clinical symptoms (91.6%). The De Ritis ratio was not significantly different between the group < 1 and the group ≥ 1 (p = 0.386). Clinical effects encountered in the study included liver fibrosis ≥ F2 assessed by APRI score in 16.7% (8 patients), OBI reactivation in 8.4% (4 patients) and HCC in 2.1% (1 patient).
Conclusions: OBI screening is needed in HBsAg - negative patients in some situations with clinical manifestations of liver fibrosis, hepatitis reactivation or HCC