TÌNH HÌNH KHÁNG KHÁNG SINH CỦA CÁC VI KHUẨN GÂY NHIỄM KHUẨN HUYẾT TẠI BỆNH VIỆN TỈNH NINH THUẬN

Abstract

Objectives: Assessing the antibiotic resistance status of bacteria causing sepsis at Ninh Thuan Provincial General Hospital.
Objects, materials and methods: Analytical cross-sectional description. Take 689 culture samples containing bacterial strains that cause sepsis isolated at Ninh Thuan Provincial General Hospital from
October 1, 2022 to September 30, 2023.
Results: Bacteria causing sepsis are 75% Gram-negative bacteria, including Escherichia coli (29.2%), Acinetobacter Baumanii (26.4%), Klebsiella pneumoniae (19.4%); 25% are Gram-positive bacteria:
Streptococcus pneumoniae (11.2%), coagulase negative Staphylococcus (8.1%), Staphylococcus aureus (5.7%). Antibiotic resistance situation: Gram-negative bacteria are highly resistant to tobramycin, cefoxitin,
cefotaxime, bactrim, cefuroxime, ceftriaxon, ciprofloxacin, ceftazidime, levofloxacin, gentamicin, cefepime, tetracycline; Gram-positive bacteria such as coagulase negative Staphylococcus are resistant to cefoxitin (100%), azithromycin (76.2%), clindamycin, oxacilline (76%), erythromycin (75.5%); Staphylococcus aureus resistant to penicillin (100%), erythromycin (94.9%), trime/sulfame (92.3%), azithromycin (91.9%), clindamycin (91.4%), cefoxitin (79.5 %), tetracycline (74.4%), oxacilline (73.5%);Streptococcus pneumoniae was resistant to trimethop-sulfamethoxazole (87%), ciprofloxacin (55.7%), levofloxacin (54.9%).
Conclusions: Gram-negative bacteria are highly resistant to beta-lactams, so consider de-escalating treatment with the initial antibiotic Carbapenem, especially in septic shock. In addition, the rate of coagulase negative Staphylococcus increases in sepsis, so more research on this agent is needed in the future.