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PREVALENCE OF ANTIBIOTIC RESISTANCE OF CARBAPENEM RESISTANT KLEBSIELLA PNEUMONIAE ISOLATED IN PATIENTS AT BAC GIANG PROVINCIAL GENERAL HOSPITAL
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Abstract
Objectives: To determine the resistance rate of Carbapenem resistant Klebsiella pneumonaie (CRKp) strains to antibiotics that isolated in patients treated at Bac Giang Provincial General Hospital.
Subjects and methods: A cross-sectional, retrospective descriptive study of 67 CRKp isolated in patients treated at Bac Giang Provincial General Hospital from January 1, 2023 to December 31, 2023.
Results: 44.8% of CRKp strains identified were class according to Ambler by phenotype method based on the Phoenix M50 identification system; the highest percentage was class D 29.9%, class B 9.0% and
class A 5.9%. The urine samples was the dominant specimen, accounted for 43.3%. CRKp were highest resistant to tier 1, including ampicillin (98.5%), ampicillin/sulbactam (89.6%),piperacyllin/tazobactam
(73.1%); cephalosporin resistance rate were 91.0% - 97.0%, quinolone resistance rate were 85.1% - 86.6%; Tier 2: Carbapenem resistance rate were 64.2% - 88.1%, cephalosporin (85.1 - 95.5%), and such resistance
rates were lowest for amikacin at 31.3%; ceftazidim/avibactam (61.2%); CRKp were resistance to tier 4 were 85.1 - 88.1%; Among CRKp isolates, 10.2% were also resistant to colistin and distribution focuses mainly on class D. All of the CRKp isolated were MDR, among them, 43.3% were XDR.
Conclusions: CRKp isolated were resistance the all antibiotic contained in the test interpreting antimicrobial susceptibility testing results for Enterobacterales: β-lactam resistance from 73.1% - 98.5%,
cephalosporin resistance from 85.1% - 97.0%, carbapenem resistance from 64.2% - 88.1%; quinolone resistance from 85.1% - 86.1%, resistace rates were lowest for amikacin at 31.3%; 10.2% resistant to colistin and distribution focuses mainly on class D
Article Details
Keywords
Carbapenem resistant Klebsiella pneumoniae, antibiotic resistance, Ambler class, colistin resistance
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