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Date Published: 25/06/2025
Abstract Views: 50
Views PDF: 25
DOI: https://doi.org/10.59873/vjid.v2i50.474
Issue
Vol. 2 No. 50 (2025): Tạp chí Truyền nhiễm Việt Nam
Section
Scientific research
How to Cite
Than, M. H., Le, V. T., Nguyen, D. H., & Nguyen, T. C. (2025). CLINICAL MANIFESTATIONS, LABORATORY AND TREATMENT OF PATIENTS DIAGNOSED WITH TUBERCULOUS MENINGITIS AT THE NATIONAL HOSPITAL FOR TROPICAL DISEASES. Vietnam Journal of Infectious Diseases, 2(50), 117-124. https://doi.org/10.59873/vjid.v2i50.474

CLINICAL MANIFESTATIONS, LABORATORY AND TREATMENT OF PATIENTS DIAGNOSED WITH TUBERCULOUS MENINGITIS AT THE NATIONAL HOSPITAL FOR TROPICAL DISEASES

Manh Hung Than, Van Trieu Le, Dinh Huong Nguyen, Trung Cap Nguyen

Main Article Content

Abstract

Tuberculous meningitis (TBM) is a relatively common form of meningitis in Vietnam, posing significant diagnostic challenges, requiring prolonged treatment, and often leading to severe sequelae.
Objectives: To describe the clinical characteristics and treatment outcomes of patients diagnosed with TBM at the National Hospital for Tropical Diseases.
Methods: A retrospective, descriptive study was conducted to analyze clinical symptoms, paraclinical findings, and pathogen identification using microbiological and molecular biological methods.
Results and conclusions: Among the study participants, 62.2% had positive microbiological results for Mycobacterium tuberculosis. The disease predominantly affected males (73.3%). The mean age was 51.2 ± 19.6 years. Fever was present in 100% of patients with microbiological evidence and 82.4% of those without (p = 0.048). Coma occurred in 31.1% of patients, and bladder/bowel dysfunction in 51.1%. The group without microbiological evidence exhibited a significantly higher percentage of lymphocytes in
cerebrospinal fluid (CSF) (64.2% vs. 47.3%, p = 0.048) and significantly higher CSF glucose levels (3.43 vs. 2.18 mmol/L, p = 0.014). Hydrocephalus was observed in 14/45 (31.1%) patients. Five out of 45 cases (11.1%) resulted in mortality. The rate of positive microbiological identification for TBM is relatively high.
Hydrocephalus is the most common complication.

Article Details

Keywords

Tuberculous meningitis,, hydrocephalus

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