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Date Published: 15/06/2025
Abstract Views: 46
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DOI: https://doi.org/10.59873/vjid.v2i50.475
Issue
Vol. 2 No. 50 (2025): Tạp chí Truyền nhiễm Việt Nam
Section
Scientific research
How to Cite
Le, Q. H., & Le, T. G. (2025). SHIFTING PATTERNS OF CAUSATIVE BACTERIA IN COMMUNITYACQUIRED BACTERIAL MENINGITIS IN POST-COVID-19 VIETNAM. Vietnam Journal of Infectious Diseases, 2(50), 117-124. https://doi.org/10.59873/vjid.v2i50.475

SHIFTING PATTERNS OF CAUSATIVE BACTERIA IN COMMUNITYACQUIRED BACTERIAL MENINGITIS IN POST-COVID-19 VIETNAM

Quoc Hung Le, Truong Giang Le

Main Article Content

Abstract

Background: Community-acquired bacterial meningitis (CABM) remains a serious infectious disease with high mortality and long-term neurological sequelae if not promptly diagnosed and treated. Recent shifts in microbial patterns and antibiotic resistance, particularly in the post-COVID-19 era, necessitate updated local epidemiological data in Vietnam.
Objectives: To describe microbiological characteristics, antibiotic susceptibility patterns, and factors associated with neurological complications and mortality in adult patients with CABM.
Methods: A retrospective observational study was conducted at a tertiary hospital in Ho Chi Minh City, including adult patients (≥ 18 years old) with positive cerebrospinal fluid cultures, admitted in 2023. Clinical, microbiological, and outcome data were analyzed using descriptive statistics and multivariate
logistic regression.
Results: Among 35 culture-confirmed cases, Gram-positive bacteria accounted for 51.4%, while Gram-negative pathogens represented 48.6%, marking a significant increase compared to previous reports. Escherichia coli and Klebsiella pneumoniae emerged as leading Gram-negative pathogens, with
high resistance to cephalosporins and fluoroquinolones. Ventricular empyema was the most common complication (42.9%) and was significantly associated with mortality. Multivariate analysis identified neurological complications as an independent predictor of death (OR = 11.5; p = 0.015).
Conclusions: This study highlights an emerging trend of increased multidrug-resistant Gram-negative pathogens and severe neurological complications in adult CABM cases in Vietnam in 2023. These findings underscore the need to update empirical treatment protocols and strengthen antimicrobial stewardship in
both hospital and community settings.

Article Details

Keywords

Bacterial meningitis, Gram-negative, antibiotic resistance, ventricular empyema, COVID-19 aftermath, Vietnam

References

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