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BACTERIAL PATHOGENS AND ANTIBIOTIC SUSCEPTIBILITY IN NEONATAL SEPSIS
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Abstract
Objectives: To investigate the causative agents and antibiotic susceptibility of bacteria in neonatal sepsis.
Subjects and methods: A longitudinal study was conducted on 78 neonates diagnosed with sepsis and positive blood cultures at the Neonatal Intensive Care Unit, Hue Central Pediatrics Hospital, from January 2021 to June 2023.
Results: In early-onset sepsis, Gram-negative bacteria accounted for 100% of cases. In late-onset sepsis, Gram-negative bacteria predominated at 80.5%, while Gram-positive bacteria accounted for 19.5%. Klebsiella pneumoniae was the most common pathogen in both early-onset (49.9%) and lateonset (34.7%) sepsis. Staphylococcus aureus was the most common Gram-positive bacterium, accounting for 18.1% of late-onset sepsis cases. There were 15/78 cases of multidrug-resistant bacteria, of which Enterobacter aerogenes was the most prevalent (9/15 cases). Antibiotics with high susceptibility rates included vancomycin (100.0%), linezolide (100.0%), and amikacin (74.6%). antibiotics with high resistance rates included ampicillin (95.5%), penicillin G (92.3%), ceftriaxone (71.0%), meropenem (60.0%), and piperacillin (59.2%).
Conclusions: Gram-negative bacteria constitute the predominant etiological agents of neonatal sepsis. The rate of antibiotic resistance among isolated bacteria is quite high, which will be a factor increasing the burden of treatment.
Article Details
Keywords
Neonatal sepsis, bacteria, antibiotic resistance
References
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