ĐÁNH GIÁ TÍNH NHẠY CẢM KHÁNG SINH CỦA CÁC VI KHUẨN GÂY NHIỄM KHUẨN HUYẾT TRÊN CÁC BỆNH NHÂN ĐIỀU TRỊ TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG GIAI ĐOẠN 2017-2020

Abstract

Background: Blood stream infection causes high morbidity and mortality rate. Antibiotic resistance of bacteria is a treatment obstacle. Determining aetiology and antibiotic susceptible contribute to optimizing antibiotics selection and improving effectiveness of treatment.

Objective: To determine bacterial aetiologies and assess antibiotic susceptibility of bacteria isolated from patients with blood stream infection treated at National Hospital for Tropical Diseases (NHTD).

Subjects and methods: A combined retrospective and prospective cross-sectional study on 200 patients with blood stream infection at NHTD from 7/2017 to 6/2020.

Result: Three major bacterial aetiologies are E. coli (32%), S. aureus (28.5%), K. pneumoniae (10%); 43.4%S. aureus strains are MRSA, 46.6% E. coli strains and 25% K. pneumoniae strains produce ESBL; E. coli and K. pneumoniae are susceptible with carbapenem (92-98%), aminoglycosides (65%-100%) and piperacillin-tazobactam (86%-96%), resistant to third-generation cephalosporins (47-50%); K. pneumoniae is still susceptible with quinolones (75%-94%) while E. coli is resistant to quinolones (48-50%). S. aureus is susceptible to vancomycin, linezolid, teicoplanin và tigecycline (100%), quinolones (75-93%), resistant to clindamycin (69%), oxacillin (62%).