TƯƠNG QUAN GIỮA NỒNG ĐỘ HBcrAg VỚI TẢI LƯỢNG HBV-DNA HUYẾT THANH Ở BỆNH NHÂN VIÊM GAN VI RÚT B MẠN TẠI BỆNH VIỆN BẠCH MAI

Abstract

Objectives: Analyzingcorrelation between HBcrAg concentration and serum HBV-DNA of chronic hepatitis B Methods: Cross-sectional descriptive prospective study of 258 chronic hepatitis B patients monitored at the Tropical Diseases Center of Bach Mai hospital from August 2020 to July 2021. Results and conclusion: The serum HBcrAg concentration correlates moderate with the serum HBV DNA concentration in a positive and linear manner (r=0.556; p=0,000), regardless of HBeAg status, regardless of HBcrAg concentration group ≥ 3 logU/ml or HBcrAg concentration < 3 logU/ml. The correlation between HBcrAg concentration with serum HBV-DNA occurred not only in treatment-naive chronic hepatitis B patients but also in treatment-experienced patients. In particular, this correlation was very strong during the EPCI phase in HBVin the natural of chronic hepatitis B and in the high serum HBV-DNA group ≥ 5 log copies/ml.