ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG Ở BỆNH NHÂN VIÊM GAN VI RÚT B MẠNTIẾN TRIỂN UNG THƯ GAN NGUYÊN PHÁT TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG

Abstract

Objective: Describe the clinical, subclinical characteristics of hepatocellular carcinoma (HCC) in chronic hepatitis B patients receiving antiviral therapy.

Objects and methods: Retrospective descriptive study of 39 patients appearing HCC during antiviral treatment at the outpatients of National Hospitalfor Tropical Diseases from January 2013 to December 2019.

Results: 74.4% of male patients. The average age was 58.0 ± 10.0. Most of patients live in rural areas (66.7%). The most common underlying disease was diabetes (10.3%). 59% of patients used alcohol. Most patients were treated with TDF (71.8%). The majority of patients, when starting antiviral therapy, showed signs of cirrhosis (82.0%), of which 33.3% showed signs of decompensated cirrhosis. The most common clinical symptoms were fatigue and anorexia (82.1%). Patients had a platelet test that was lower than normal values (131.1 ± 85.5). Fibroscan index of liver fibrosis was high (26.7 ± 22.9). HCC prediction scale value: CU- HCC at high risk level (16.8 ± 15.1).

Conclusion: Patients who develop HCC during antiviral treatment had the following characteristics: old age, male, living in rural areas, habit of alcohol use, late treatment of antiviral drugs when available cirrhosis and decompensated cirrhosis. Subclinical tended to have features of cirrhosis.