TỶ LỆ NHIỄM VÀ TÍNH KHÁNG THUỐC CỦA MỘT SỐ CHỦNG NẤM CANDIDA GÂY BỆNH PHÂN LẬP TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG (1/2017-12/2018)

Abstract

Objectives: Evaluate the infection rate and drug resistance level of isolated Candida strains that cause diseases.

Objects and methods: A cross-sectional study combined with retrospective was conducted from January 2017 to December 2018 on 403 pathogenic Candida strains isolated from samples of hospitalized patients treated at The National Hospital of Tropical Diseases.

Resuls-conclusions: Candida accounts for 49.2% of the total 819 pathogenic fungi positive specimens isolated. Candidaemia accounts for 17.1% (44/257) (ranked second after T. marnefei). In which C. albicans accounts for the highest rate 48.9% (22/45); the second  is C. parasilosis with 13.3% (6/45); C. tropicalis with 11.1% (5/45). C. tropicalis is becoming the main cause of disease in urinary tract infections due to fungus, accounting for the highest proportion of 52.2% (105/201); the second is C. albicans with 32.3% (65/201). In the sterile fluid sample (peritoneal fluid/abdominal fluid, liver abscess), Candida is ranked second (after T. marnefei) 6/42 cases, accounting for 14.3% (5/6 cases were C. albicans). Fluconazole is the first drug in preventive treatment, with the lowest susceptibility rate to Candida species is 86.3% (C. parasilosis is 85,7%; C. glabrata is 91.7%). C. tropicalis strains that are still susceptible to fluconazole and voriconazole are 72.7% and 81.8%, respectively. Echinocandins were 100% susceptible to strains of C. parasilosis and Candida spp, but decreased susceptibility to C. glabrata (CAS and MCF are 96.6%) and C. albicans (MCF is 96.5%). Amphotericin B remains susceptible (94.8%) to the genus Candida in general, higher than voriconazole and fluconazole, second only to echinocandins and flucytosine.