ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA BỆNH NHÂN NHIỄM RICKETTSIA TYPHI TẠI VIỆT NAM

Abstract

Murine typhus is a flea-borne disease caused by Rickettsia typhi. Although this disease was discovered recently, it has become widespread all over the world. Murine typhus is a common disease of rats and small mammals with rat flea (Xenopsylla cheopis) as the vector of transmission. People infected with R.typhi via the faeces of flea infiltrate through: stings, scratched skin, inhalation, mucosa contamination with various clinical manifestations.

Objectives: To describe clinical and subclinical characteristics for patients with R.typhi.

Subjects and methods: Descriptive cross-sectional study on patients with fever and positive realtime PCR result for R.typhi at different research areas from 8 Vietnamese ecological regions throughout the period from June 2018 to June2019.

Results: clinical manifestations of R.typhi infected patients included: fever (100%), headache (94.64%), myalgia (62.5%), skin congestion (78.57%), conjunctival congestion (50%), rash (41.07%). The rate of patients with peripheral leukocytosis was 25%, neutropenia was 50%, there were 69.64% of patients with thrombocytopenia. 100% of patients had increased CRP, the rate of patients with increased AST was 66.67%, the increase of ALT was 95.12%.

Conclusion: Murine typhus has diverse clinical and subclinical manifestations and is quite diverse and non-specific.