THỰC TRẠNG KHÁNG KHÁNG SINH CỦA MỘT SỐ TRỰC KHUẨN GRAM ÂM ĐƯỢC PHÂN LẬP TẠI BỆNH VIỆN VIỆT TIỆP HẢI PHÒNG NĂM 2020

Abstract

Summary: Nowaday antibiotic resistance is the most serious threat to human health. There are some bacterias which are already resistant to almost antobiotics. Purpose: Evaluate the current situation of antibiotic resistance of pathogenic gram-negative bacilli which was isolated at Viettiep hospital, 2020.

Subjects and methods: All cultured specimens of common pathogenic gram-negative bacilli at Viettiep hospital, 2020. Research method: cross sectional description.

Results: 2760 strains of pathogenic gram-negative baclli were isolated. Of 2260, 55.96% of E.Coli produced ESBL. The rate of  E. coli resistant to antibiotic was: cefotaxime: 63.37%; cefuroxime: 56.97%; ceftazidime: 34.83%,ciprofloxacin: 68.52%; ertapenem: 3.73%; imipenem: 2.72%; meropenem: 2.85%. The rate of K.pneumoniae resistant to antibiotic was: amoxicillin/clavulanicacid: 51.01%; cefotaxime: 50.0 %; piperacillin/tazobactam: 45.0%; ceftazidime: 45.09%; cefuroxime: 37.24%; cefepime: 33.33%, ciprofloxacin: 57.29%; ertapenem: 31.29%; imipenem: 27.69%, meropenem: 28.13%. The rate of P.aeruginosa resistant to antibiotic was: ciprofloxacin: 54.08%,  gentamicin: 51.74%; tobramycin: 46.92%; meropenem: 46.30%;  amikacin: 36.01%; imipenem: 35.76%; ceftazidime: 33.90%, cefepime: 28.57%; piperacillin/tazobactam: 14.38%. The rate of A.baumannii resistant to β-lactam antibiotic was: ampicillin/sulbactam: 63.91%; piperacillin/tazobactam: 88.14%; ceftazidime: 85.26%; cefotaxime: 83.08%; cefepime: 83.57%; imipenem: 83.05%; meropenem: 84.36%.

Conclusions: Antibiogram results showed that isolated of gram-negative bacilli had a high rate of resistance to 3^rd cephalosporin and ciprofloxacin. Carbapenemes resistance of K.pneumoni, A.baunannii strains are extremely serious.