ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG Ở BỆNH NHÂN NHIỄM KHUẨN HUYẾT DO E. COLI TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG GIAI ĐOẠN 2015- 2020

Abstract

Objective: To describe the clinical and paraclinical manifestations of blood stream infection caused by E. coli in patients treated at the National Hospital for Tropical Diseases (NHTD), period 2015-2020.

Subjects and methods: In this cross-sectional retrospective study, 120 adult patients with blood culture-confirmed E. coli was recruited from National Hospital for Tropical Diseases from July 2015 to June 2020.

Result: The most common clinicalmanifestations of blood stream infection caused by E.coli at admission were urinary tract infections (39.17%), respiratory infections (31.67%) and gastrointestinal infections (25.83%). Laboratory results at admission included anemia (59,66%), thrombocytopenia (52.94%), decreased prothrombin (46.23%), acute kidney faillure (23.73%), PCT > 10 ng/ml (56.78%), CRP >100 mg/L (68.97%).Septic shock accounted for 16.67%. A half of patients progressed to septic shock in the first 3 days after the onset of symptoms. The rate of cirrhosis and cancer history (50% and 20%) was significantly higher in patients with septic shock than in patients without septic shock(17% and 5%, p <0.05).  Patients with septic shock also had higher rates of anemia(85%), leucopenia< 4 G/l (20%), thrombocytopenia (95%), increased creatininemia(65%), and increased bilirubinemia (77.8%) than patients without septic shock.

Conclusions: In patients with blood stream infection caused by E.coli, laboratory testing results at admission can suggest the progression of septic shock. Therefore, more studies on blood stream infection and septic shock caused by E.coli are recommended.